top of page
NTI-121: SLNP-IC1/TR12 Nammisome
Formulation Solid Lipid NanoParticle (SLNP) with Doxorubicin prodrug (IC1) and Toll Receptor 7 agonist prodrug (TR12) incorporated.
IC1 rationale: Doxorubicin is a widely used chemotherapeutic drug. Liposome encapsulated form of Doxorubicin shows superiority to free doxorubicin clinical performance in a variety of neoplastic conditions but yet faces challenges such as poor stability. Incorporating the Doxorubicin prodrug in a Nammisome improves drug stability, efficacy, and safety.
TR12 rationale: Toll receptor 7 agonists are clinically validated to have anti-tumor activity but are generally too potent to give as free drugs. Incorporation of the prodrug in a Nammisome targets the activity to tumors while reducing systemic activity allowing for safe delivery of effective doses.
Target Indications: While the immune mechanisms targeted by AR5/TR5 are independent of cancer type, the mechanism of selective tumor delivery of Nammisomes is dependent on presence of a tumor mass (as opposed to dispersed cells). Therefore, solid tumors would be the potential market for this product. Initial development will be determined by done in multiple indications to demonstrate efficacy in a large indication such as breast cancer and in an indication with Orphan Drug Potential such as bladder, pancreatic, and renal cancers.
Mechanistic Validation of LNP-AR5/TR5
LNP-prodrugs are more potent than free drugs
NTI-55: Anti-Tumor Efficacy in Vivo
Efficacy in a Murine Model of Breast Cancer (EMT6)
NTI-55 Efficacy in Murine Colon Cancer Model (MC38)
bottom of page